Since our universal embed code is non-blocking, Disqus doesn't make any significant impact to a page's overall load time.
In general, regarding overall page performance, we are always working hard to make sure that we don't add any performance regressions to sites using Disqus.
Disqus did provide a blocking embed code pre-early 2010. If you are still using this embed code, we recommend updating to the latest embed code.